Juhi Singh [website in progress]

@article{antibiotic_tma_therapeutic_methacrylic_c_16,
    author = "Singh, Juhi and Mandell, Jonathan B and Scheidt, Josef and Orlando, Jason D and Kadir, Jacob C and Ribnick, Whitney B and Brothers, Kimberly M and Urish, Kenneth L and Sydlik, Stefanie A",
    abstract = "Bone infections are common complications of joint replacement surgeries. Standard antibiotic therapies often fail due to compromised blood supply and bacterial growth on prosthetics. Currently, localized antibiotic delivery is accomplished by antibiotic‐loaded bone cements (ALBCs). However, ALBCs lack the required mechanical strength. To address these limitations, therapeutic gentamicin methacrylic comonomers (gMAs) are developed. These comonomers use a methacrylic carbonyl bond for hydrolytically controlled drug release, and actively contribute to poly (methyl methacrylate) cement curing, enhancing strength. Structure‐property relationships evaluate mechanical properties of fresh and aged cements, release behavior, and antibacterial performance with respect to type of tether bond, and gMA loading percentage (3–10\%). gMA‐loaded cements match clinical strength, even at 10\% loading, with …",
    journal = "Advanced Functional Materials",
    number = "1",
    pages = "2406126",
    title = "Antibiotic TMA (Therapeutic Methacrylic) Comonomers: Synergizing Mechanical Integrity with Infection Control in Bone Cement",
    url = "https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202406126",
    volume = "35",
    year = "2025"
}

@article{polyurethane_grafted_graphene_oxide_from_15,
    author = "Vickery, Walker M and Singh, Juhi and Orlando, Jason D and Lin, Ting-Chih and Wang, Julia and Sydlik, Stefanie A",
    abstract = "Polyurethanes (PU) make up a large portion of commodity plastics appearing in applications including insulation, footwear, and memory foam mattresses. Unfortunately, as thermoset polymers, polyurethanes lack a clear path for recycling and repurposing, creating a sustainability issue. Herein, using dynamic depolymerization, we demonstrate a simple one-pot synthesis for preparation of an upcycled polyurethane grafted graphene material (PU–GO). Through this dynamic depolymerization using green conditions, PU–GO nanofillers with tunable PU to GO ratios were synthesized. Chemical analysis revealed that the polyurethane graphenic materials primarily contained the polycarbamate hard-segment of polyurethane while the soft polyol component was removed in washes. PU–GOs were incorporated into bulk polyurethane foam to create composites as a filler at 0.25, 0.5, 1.0, and 2.0 weight percent filler and …",
    journal = "RSC advances",
    number = "4",
    pages = "2737-2748",
    publisher = "Royal Society of Chemistry",
    title = "Polyurethane-grafted graphene oxide from repurposed foam mattress waste",
    url = "https://pubs.rsc.org/en/content/articlehtml/2025/ra/d4ra06691j",
    volume = "15",
    year = "2025"
}

@article{the_role_and_future_of_functional_graphe_14,
    author = "Arnold, Anne M and Singh, Juhi and Sydlik, Stefanie A",
    abstract = "Functional graphenic materials (FGMs) are materials derived from graphene oxide (GO) that hold a plethora of applications from electronics to nanomedicine. In this Perspective, we examine the history and evolution of biomedical applications of this carbon-based macromolecule. Following the carbon nanotube (CNT) movement, GO and FGMs became nanocarbons of interest because of their low cost and versatile functionality. The tunable chemistry enabled our work on FGMs coupled with biomacromolecules and allows FGMs to plays an important role in many biomedical applications, from tissue regeneration to controlled delivery. As we work to develop this material, it is critical to consider toxicity implications─in fresh materials as well as in degradation products. With this understanding, FGMs also hold potential roles in human health and environmental sustainability, making FGMs an important contemporary …",
    number = "4",
    pages = "2015-2042",
    publisher = "American Chemical Society",
    title = "The Role and Future of Functional Graphenic Materials in Biomedical and Human Health Applications",
    url = "https://pubs.acs.org/doi/abs/10.1021/acs.biomac.4c01431",
    volume = "26",
    year = "2025"
}

@article{color_changing_bioadhesive_barrier_for_p_18,
    author = "Djordjevic, Ivan and Ellis, Elizabeth and Singh, Juhi and Ali, Naziruddin and Pena, Edgar M and Rajarethinam, Ravisankar and Manikandan, Lakshmanan and Goh, Jason and Lim, Sierin and Steele, Terry",
    abstract = "Bacteria migration at catheter insertion sites presents a serious complication (bacteraemia) with high mortality rates. One strategy to mediate bacteraemia is a physical barrier at the skin-catheter interface. Herein a colorimetric biosensor adhesive (CathoGlu) is designed and evaluated for both colorimetric detection of bacterial infection and application as a bacteria barrier. The design intent combines viscous, hydrophobic bioadhesive with an organic pH indicator (bromothymol blue). Visual observation can then distinguish healthy skin at pH = ∼5 from an infected catheter insertion site at pH = ∼8. The liquid-to-biorubber transition of CathoGlu formulation occurs via a brief exposure to UVA penlight, providing an elastic barrier to the skin flora. Leachates from CathoGlu demonstrate no genotoxic and skin sensitization effect, assessed by OECD-recommended in vitro and in chemico assays. The CathoGlu formulation …",
    journal = "Biomaterials Science",
    number = "6",
    pages = "1502-1514",
    publisher = "Royal Society of Chemistry",
    title = "Color changing bioadhesive barrier for peripherally inserted central catheters",
    url = "https://pubs.rsc.org/en/content/articlehtml/2024/bm/d3bm01347b",
    volume = "12",
    year = "2024"
}

@article{synthesis_and_applications_of_bacterial__17,
    author = "Singh, Juhi and Basu, Anindya and Lim, Sierin",
    abstract = "Bacterial cellulose (BC) has been attracting attention for its utilities in a variety of applications. Its nanofibrous nature offers a high surface area for the formulation of composites through physical, chemical, or biological methods. BC composites have been formed by combining with a wide range of molecules to impart additional functions. This chapter summarizes the additives and techniques to modify BC to form nanocomposites for applications in different industrial sectors. The chapter starts with an overview of BC s unique properties that are essential for composite design. The types of additives or reinforcement agents utilized to form composites are discussed, followed by techniques employed to formulate the composites. The last section showcases the applications of BC and BC composites in the areas of pharmaceuticals, food, diagnostics, cosmetics and as a general matrix.",
    pages = "121-169",
    publisher = "Bentham Science Publishers",
    title = "Synthesis and Applications of Bacterial Cellulose Composites",
    url = "https://www.benthamdirect.com/content/books/9789815136869.chapter-5",
    year = "2024"
}

@article{bacterial_cellulose_adhesive_patches_des_8,
    author = "Singh, Juhi and Steele, Terry WJ and Lim, Sierin",
    abstract = "The wet environment in the oral cavity is challenging for topical disease management approaches. The compromised material properties leading to weak adhesion and short retention (<8 h) in such environment result in frequent reapplication of the therapeutics. Composites of bacterial cellulose (BC) and carbene-based bioadhesives attempt to address these shortcomings. Previous designs comprised of aqueous formulations. The current design, for the first time, presents dry, shelf-stable cellulose patches for convenient ready-to-use application. The dry patches simultaneously remove tissue surface hydration while retaining carbene-based photocuring and offers on-demand adhesion. The dry patch prototypes are optimized by controlling BC/adhesive mole ratios and dehydration technique. The adhesion strength is higher than commercial denture adhesives on soft mucosal tissues. The structural integrity is …",
    journal = "Biomaterials Advances",
    pages = "213174",
    publisher = "Elsevier",
    title = "Bacterial cellulose adhesive patches designed for soft mucosal interfaces",
    url = "https://www.sciencedirect.com/science/article/pii/S2772950822004514",
    volume = "144",
    year = "2023"
}

@article{environmental_and_health_impacts_of_func_13,
    author = "Vickery, Walker M and Wood, Hunter B and Orlando, Jason D and Singh, Juhi and Deng, Chenyun and Li, Li and Zhou, Jing-Yi and Lanni, Frederick and Porter, Aidan W and Sydlik, Stefanie A",
    abstract = "Graphenic materials have excited the scientific community due to their exciting mechanical, thermal, and optoelectronic properties for a potential range of applications. Graphene and graphene derivatives have demonstrated application in areas stretching from composites to medicine; however, the environmental and health impacts of these materials have not been sufficiently characterized. Graphene oxide (GO) is one of the most widely used graphenic derivatives due to a relatively easy and scalable synthesis, and the ability to tailor the oxygen containing functional groups through further chemical modification. In this paper, ecological and health impacts of fresh and ultrasonically altered functional graphenic materials (FGMs) were investigated. Model organisms, specifically Escherichia coli, Bacillus subtilis, and Caenorhabditis elegans, were used to assess the consequences of environmental exposure to fresh …",
    journal = "NanoImpact",
    pages = "100471",
    publisher = "Elsevier",
    title = "Environmental and health impacts of functional graphenic materials and their ultrasonically altered products",
    url = "https://www.sciencedirect.com/science/article/pii/S2452074823000228",
    volume = "31",
    year = "2023"
}

@article{self_regulating_bioadhesives_for_wet_sub_19,
    author = "Lim, Sierin and Steele, Terry William Joseph and Singh, Juhi",
    abstract = "Herein disclosed is a mucoadhesive including a bacterial cellulose, and a bioadhesive incorporated to the bacterial cellulose, wherein the bioadhesive comprises a polymer or a dendrimer, wherein the polymer and the dend rimer are grafted with a moiety which forms covalent interactions with a tissue surface in the presence of a stimulus. A method of forming the mucoadhesive is also disclosed. The method includes providing a bacterial cellulose, providing a bioadhesive comprising a polymer or a dendrimer, wherein the polymer and the dendrimer are grafted with a moiety which forms covalent interactions with a tissue surface in the presence of a stimulus, and incorporating the bioadhesive to the bacterial cellulose. In the preferred embodiment, the dendrimer grafted with the moiety is Poly (amidoamine)(PAMAM) dendrimer grafted with 4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl bromide (PAMAM-g-diazirine …",
    title = "Self-regulating bioadhesives for wet substrates",
    url = "https://patents.google.com/patent/US20230390191A1/en",
    year = "2023"
}

@article{water_activated_catechol_adhesive_allows_11,
    author = "Ghosh, Animesh and Singh, Juhi and Lim, Sierin and Steele, Terry WJ",
    abstract = "Bioadhesives comprising of catechol crosslinkers have displayed broad utility against both soft and hard substrates. However, catechol's two-part adhesion chemistry requires oxidative chemicals that are detrimental to organic substrates. Herein, a water-activated adhesive with inherent antibacterial properties is prepared by grafting catechol groups onto branched polyethylenimine (PEI-DBA20). The resultant PEI-DBA20 is stable in organic solvents but undergoes curing in the presence of water. The in-built oxidation method relies on the close proximity of catechol/Schiff base functional groups that form tautomers in the presence of aqueous solvents. The curing mechanism is demonstrated by dip coating hydrated substrates, where the grafted dendrimers subsequently crosslink and form thin films. Coated PET films and polyester textiles exhibit an antimicrobial surface with 4–6 log reduction against model Gram …",
    journal = "Materials Today Advances",
    pages = "100398",
    publisher = "Elsevier",
    title = "Water activated catechol adhesive allows dip coated antimicrobial coatings",
    url = "https://www.sciencedirect.com/science/article/pii/S2590049823000589",
    volume = "19",
    year = "2023"
}

@article{design_of_bacterial_cellulose_adhesives__21,
    author = "Singh, Juhi",
    abstract = "Wet and dynamic environment of the oral cavity poses challenges for topical disease management approaches. Conventional treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6-8 hours), frequent dosing requirement and patient incompliance. Mucoadhesive drug delivery platforms are proposed herein for oral wound sites with soft tissue adhesion capability and ability to retain structural integrity in wet environments. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives are combined to yield flexible film platforms for interfacing soft tissues in dynamic, wet environments. Three platforms are presented in this thesis that are (1) layered composites, (2) fibrillated BC and carbene bioadhesive based hydrogels and (3) integrated adhesive patches. The first platform consists of carbene bioadhesive layered onto dry BC matrix and is referred to as 2-component layered composite. Structure-activity relationships evaluate UVA dose and hydration state with respect to adhesive strength on soft tissue mimics. The layered composite has an adhesion strength ranging from 7-17 kPa and duration exceeding 48 hours in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5-5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity. The layered composites however exhibit fracture in the adhesive matrix owing to non-homogenous carbene bioadhesive layer. Moreover, the composites could not be …",
    publisher = "Nanyang Technological University",
    title = "Design of bacterial cellulose adhesives for wet tissue adhesion in oral cavity",
    url = "https://dr.ntu.edu.sg/handle/10356/164968",
    year = "2022"
}

@article{hybrid_polymer_networks_of_carbene_and_t_9,
    author = "Djordjevic, Ivan and Wicaksono, Gautama and Singh, Juhi and Singh, Manisha and Ellis, Elizabeth G and Alraddadi, Maher A and Dove, Andrew P and Steele, Terry WJ",
    abstract = "Thiol/ene-based resorbable elastomers display tough elongation but lack adhesion to soft tissues. Carbene-based bioadhesives (e.g. CaproGlu) allow soft tissue adhesion, but the covalent crosslinks limit extensibility after photoactivation. Herein thiol/ene resorbable elastomers are combined with a carbene bioadhesive into a 3-component hybrid network by exploiting tunable photoactivation of each macromolecule independently or simultaneously. Dual crosslinking was monitored by photorheometry, where 405 nm initiates formation of a thiol/ene elastomeric network, followed by 365 nm activation of diazirine-grafted polycaprolactone tetrol (CaproGlu). Dynamic shear moduli, gelation point, elongation at break, and lap shear stress of the hybrid polymer network are evaluated with respect to absorbed light energy dose. Surface-exposed unreacted CaproGlu enables adhesion of the hybrid network to various …",
    journal = "European Polymer Journal",
    pages = "111502",
    publisher = "Pergamon",
    title = "Hybrid polymer networks of carbene and thiol ene",
    url = "https://www.sciencedirect.com/science/article/pii/S0014305722005067",
    volume = "178",
    year = "2022"
}

@article{self_regulating_bioadhesives_for_wet_sub_20,
    author = "LIM, Juhi Singh Sierin and STEELE, Terry William Joseph",
    title = "Self-regulating bioadhesives for wet substrates",
    year = "2022"
}

@article{bacterial_cellulose_adhesive_composites__5,
    author = "Singh, Juhi and Tan, Nigel CS and Mahadevaswamy, Usha Rani and Chanchareonsook, Nattharee and Steele, Terry WJ and Lim, Sierin",
    abstract = "Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments …",
    journal = "Carbohydrate Polymers",
    pages = "118403",
    publisher = "Elsevier",
    title = "Bacterial cellulose adhesive composites for oral cavity applications",
    url = "https://www.sciencedirect.com/science/article/pii/S0144861721007906",
    volume = "274",
    year = "2021"
}

@article{fibrilated_bacterial_cellulose_liquid_ca_12,
    author = "Singh, Juhi and Steele, Terry WJ and Lim, Sierin",
    abstract = "Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6–8 hours), frequent dosing requirement and patient incompatibility. To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces. The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels. The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues. The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film). The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.",
    journal = "Journal of Materials Chemistry B",
    publisher = "Royal Society of Chemistry",
    title = "Fibrilated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces",
    url = "https://pubs.rsc.org/en/content/articlehtml/2021/tb/d1tb02044g",
    year = "2021"
}

@article{hydrogel_based_drug_delivery_systems_for_10,
    author = "Mishra, Brahmeshwar and Singh, Juhi",
    abstract = "Hydrogels have been employed for applications like wounds, burns, dressings, contact lenses, tissue engineering applications, to name a few. The potential of hydrogel application for localized cancer therapy has also been widely explored. This chapter aims to provide an insight into the injectable hydrogel systems for local application to the tumor site. The chapter discusses the basics of hydrogel and its classification. The hydrogels are classified according to their triggering stimuli like pH, temperature, magnet, light, and ultrasound are discussed in detail. The basic design and mechanism of action of several stimuli-responsive hydrogels with few researched examples are discussed. In the end, an overview of the marketed and patented hydrogels for cancer therapy has been provided.",
    pages = "63-74",
    publisher = "Academic Press",
    title = "Hydrogel-based drug delivery systems for cancer therapy",
    url = "https://www.sciencedirect.com/science/article/pii/B9780323855037000110",
    year = "2021"
}

@article{rapid_activation_of_diazirine_biomateria_6,
    author = "Djordjevic, Ivan and Wicaksono, Gautama and Solic, Ivan and Singh, Juhi and Kaku, Tanvi Sushil and Lim, Sierin and Ang, Elwin Wei Jian and Blancafort, Lluis and Steele, Terry WJ",
    abstract = "Carbene-based macromolecules are an emerging new stimuli-sensitive class of biomaterials that avoid the impediments of free radical polymerization but maintain a rapid liquid-to-biorubber transition. Activation of diazirine-grafted polycaprolactone polyol (CaproGlu) is limited to UVA wavelengths that have tissue exposure constraints and limited light intensities. For the first time, UVA is circumvented with visible light-emitting diodes at 445 nm (blue) to rapidly activate diazirine-to-carbene covalent cross-linking. Iridium photocatalysts serve to initiate diazirine, despite having little to no absorption at 445 nm. CaproGlu’s liquid organic matrix dissolves the photocatalyst with no solvents required, creating a light transparent matrix. Considerable differences in cross-linking chemistry are observed in UVA vs visible/photocatalyst formulations. Empirical analysis and theoretical calculations reveal a more efficient conversion …",
    journal = "ACS Applied Materials \& Interfaces",
    number = "31",
    pages = "36839-36848",
    publisher = "American Chemical Society",
    title = "Rapid activation of diazirine biomaterials with the blue light photocatalyst",
    url = "https://pubs.acs.org/doi/abs/10.1021/acsami.1c08581",
    volume = "13",
    year = "2021"
}

@article{sunlight_activated_film_forming_adhesive_7,
    author = "Tan, Nigel CS and Djordjevic, Ivan and Malley, Jamie Ann and Kwang, Ailyn LQ and Ikhwan, Syed and Šolić, Ivan and Singh, Juhi and Wicaksono, Gautama and Lim, Sierin and Steele, Terry WJ",
    abstract = "Stimuli-sensitive biomaterials that are activated by light are in need of formulations that are stable under indoor lighting yet can be activated under direct sunlight. Carbene-based bioadhesives are a new generation of film-forming polymers that are stable under indoor lighting yet are rapidly activated with low-energy UVA light, but have never been evaluated under sunlight exposure. Previous investigations have evolved two flexible carbene-based platforms, where aryl-diazirine is grafted on to polyamidoamine dendrimers (PAMAM-NH2; generation-5) or hydrophobic liquid polycaprolactone tetrol to yield G5-Dzx and CaproGlu, respectively. For the first time the activation of G5-Dzx and CaproGlu is investigated by natural sunlight with intensities up to 10 mW·cm−2. Structure-property relationships of bioadhesion are investigated by: (1) joules dose of sunlight; (2) bioadhesive polymer structure; and (3) optical …",
    journal = "Materials Science and Engineering: C",
    pages = "112240",
    publisher = "Elsevier",
    title = "Sunlight activated film forming adhesive polymers",
    url = "https://www.sciencedirect.com/science/article/pii/S0928493121003805",
    volume = "127",
    year = "2021"
}

@article{assessing_the_viability_of_soluplus_self_4,
    author = "Bonde, Gunjan Vasant and Ajmal, Gufran and Yadav, Sarita Kumari and Mittal, Pooja and Singh, Juhi and Bakde, Bharati V and Mishra, Brahmeshwar",
    abstract = "Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated toxicity. Thus, in the present study, we fabricated self-assembled nanocolloidal polymeric micelles (LP-PMs) of Soluplus® and Pluronic® F127 by the thin-film hydration method and assessed their delivery potential of the hydrophobic anti-cancer drug lapatinib (LP) and optimised these nanocolloidal polymeric micelles using Quality-by-Design approach. Amorphisation of the drug and no typical incompatibility other than hydrogen bonding in the LP-PMs was confirmed by solid-state characterisation. The LP-PMs exhibited a uniform size of 92.9 ± 4.07 nm, with a 5.06 mV zeta potential and approximately 87\% drug encapsulation. The critical micellar …",
    journal = "Colloids and Surfaces B: Biointerfaces",
    pages = "110611",
    publisher = "Elsevier",
    title = "Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation",
    url = "https://www.sciencedirect.com/science/article/pii/S0927776519307556",
    volume = "185",
    year = "2020"
}

@article{novel_drug_delivery_systems_and_signific_2,
    author = "Mishra, Brahmeshwar and Singh, Juhi",
    abstract = "Pulmonary drug delivery offers targeted therapy for the treatment of respiratory diseases such as asthma, lung cancer, and chronic obstructive pulmonary diseases. However, this route poses challenges like deposition mechanism, drug instability, and rapid clearance mechanism. Other factors like the type of inhaler device, patient compatibility, consistent delivery by device, and inhaler technique also affect the performance of pulmonary delivery systems. Thus, to overcome these issues, pulmonary delivery systems utilizing particle-based approaches (nano/microparticles) have emerged in the last two decades. This chapter provides insight into various mechanisms of pulmonary drug administration, the ideal requirements of a pulmonary system, and the general devices used for pulmonary delivery. An overview of new pulmonary delivery systems and their relevance in the treatment of respiratory diseases is …",
    pages = "57-95",
    publisher = "Elsevier",
    title = "Novel drug delivery systems and significance in respiratory diseases",
    url = "https://www.sciencedirect.com/science/article/pii/B9780128206584000042",
    year = "2020"
}

@article{ciprofloxacin_hcl_and_quercetin_function_1,
    author = "Ajmal, Gufran and Bonde, Gunjan Vasant and Thokala, Sathish and Mittal, Pooja and Khan, Gayasuddin and Singh, Juhi and Pandey, Vivek Kumar and Mishra, Brahmeshwar",
    abstract = "Microbial infection and oxidative damage of the fibroblast often results in prolonged and incomplete wound healing. Therefore, there is an increasing demand for a scaffold being effective to prevent any possible infection and neutralize excessively released free radicals. Herein, we designed a PCL-based nanofiber loaded with ciprofloxacin hydrochloride (CHL) and quercetin. Developed nanofiber showed the formation of smooth and continuous nanofiber with 101.59 ± 29.18 nm average diameter and entrapping the drugs in amorphous form without any possible physico-chemical interaction between drugs and excipient. High entrapment efficiency (CHL: 92.04\% and Que: 94.32\%) and prolonged in-vitro release (for 7 days) demonstrated the capability of scaffold to suppress any probable infection and oxidative damage, which was further confirmed by in-vitro antibacterial and antioxidant activity. The …",
    journal = "Artificial cells, nanomedicine, and biotechnology",
    number = "1",
    pages = "228-240",
    publisher = "Taylor \& Francis",
    title = "Ciprofloxacin HCl and quercetin functionalized electrospun nanofiber membrane: fabrication and its evaluation in full thickness wound healing",
    url = "https://www.tandfonline.com/doi/abs/10.1080/21691401.2018.1548475",
    volume = "47",
    year = "2019"
}

@article{design_optimization_characterization_and_3,
    author = "Singh, Juhi and Mittal, Pooja and Bonde, Gunjan Vasant and Ajmal, Gufran and Mishra, Brahmeshwar",
    abstract = "Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics. The present work aimed at formulation of Quercetin loaded Soluplus® micelles (SMs) so as to enhance its bioavailability and provide prolonged release for the management of diabetes. Box-Behnken response surface methodology was employed to optimize the formulation prepared using co-solvent evaporation method. Physicochemical characterization confirmed the nano-spherical nature of Quercetin loaded Soluplus® micelles (Qu-SMs) with average particle size ranging from 85-108nm, encapsulation efficiency of 63-77\%. Solid state characterization confirmed the encapsulation of Qu in the …",
    journal = "Artificial Cells, Nanomedicine, and Biotechnology",
    number = "sup3",
    pages = "S546-S555",
    publisher = "Taylor \& Francis",
    title = "Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment",
    url = "https://www.tandfonline.com/doi/abs/10.1080/21691401.2018.1501379",
    volume = "46",
    year = "2018"
}

@article{preparation_characterization_and_in_vivo_0,
    author = "Bairagi, Ujjawal and Mittal, Pooja and Singh, Juhi and Mishra, Brahmeshwar",
    abstract = "Diabetes mellitus is most common disorder characterize by hyperglycemia. Chronic hyperglycemia may lead to over production of free radicals thereby results in oxidative stress which impaired healing of wounds. Ferulic acid (FA) has been shown to have antidiabetic and antioxidant properties. The aim of the present study was to develop Ferulic acid nanoparticles and to study its hypoglycemic and wound healing activities. Ferulic acid-poly(lactic-co-glycolic acid) (FA-PLGA) nanoparticles were prepared by nano precipitation method. The prepared FA-PLGA nanoparticles had an average size of 240 nm. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis showed the prepared FA-PLGA nanoparticles were spherical in shape. Drug encapsulation assay showed that 88.49\% FA was encapsulated in PLGA. Carbopol 980 was used to formulate FA-PLGA nanoparticles loaded hydrogel …",
    journal = "Drug development and industrial pharmacy",
    number = "11",
    pages = "1783-1796",
    publisher = "Taylor \& Francis",
    title = "Preparation, characterization, and in vivo evaluation of nano formulations of ferulic acid in diabetic wound healing",
    url = "https://www.tandfonline.com/doi/abs/10.1080/03639045.2018.1496448",
    volume = "44",
    year = "2018"
}